Neuroinflammatory Processes in Stroke and Alzheimer's Disease

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ECTS and Course type

ECTS: 2.5

Course type:Lecture/seminar

Target audience

MSc, PhD; open to other programs.

Short introduction

Over the past decade the role of neuroinflammation in neurological disorders has been increasingly recognized to be not only a bystander but an active contributor to pathogenesis. This course is aimed at providing students with a general background on the role of immune and glial cells in diseases of the CNS and to gain a more specific overview of neuroinflammation in stroke and Alzheimer's disease.

Date and time

Tuesdays 08.01.-26.02.2019, 16:30 – 18:00

8 sessions in total, 90min each

Location

Humboldt Graduate School
Luisenstr. 56
10117 Berlin

Room 122
Room 220 on 19 February 2019

Learning outcome

The course is designed for students to actively learn about current concepts of neuroinflammation through the presentation of recent journal articles. For each session, two pre-selected papers will be presented that will highlight and contrast the still unclear role of neuroinflammatory processes in the respective disease context (Alzheimer's disease and stroke). After each presentation, students are encouraged to critically discuss the paper and to put it into context with previous research.

Structure

  • Session 1: Introductory lectures on basic immunology, glia in the CNS as well as innate and adaptive immune actions in Alzheimer's disease and stroke.
  • Sessions 2-4: In each session two papers will be presented on current concepts of Alzheimer's disease. The first paper will be presented by one or two students (20-30 minutes) which will be followed by a 15 minute discussion. Then, the second paper will be presented in similar format.
  • Sessions 5-7: In each session two papers will be presented on current concepts of stroke research. The first paper will be presented by one or two students (20-30 minutes) which will be followed by a 15 minute discussion. Then, the second paper will be presented in similar format.
  • Session 8: Closing session with closing statements and summary of the course (45 min) followed by a feedback round and Q&A session (45 min).

Guiding tasks and questions for paper preparation

For their paper presentation the students should prepare the following key points:

  • Introduction and hypothesis
  • Summary of methods and most important findings
  • Did the methods used answer the hypothesis? 
  • How to the results stand out from previous findings in the field?
  • Critical evaluation of results

Assignments/Exam

Depending on the size of the course, one or two students will be required to present a pre-selected journal article each.